JP
Labs and Faculty
Inter-Institutional Cooperative Laboratories
Laboratory of Cancer Biology

TSUCHIHARA Katsuya Prof. M.D., Ph.D.

Other Affiliations: Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center Japan
Theme

Tumor diagnostics, Tumor biology

Keyword

Cancer genomics, Clinical sequence, Database

Message

High quality clinical information is necessary for the development of cancer therapies. In addition, data from multi-omics analysis of genome, transcriptome, and microbiome using patient samples and animal and cell models is also essential. Informatics is essential for integrating these data and deriving new knowledge. We are engaged in research and development of various data processing pipelines, database construction, optimization techniques for information extraction, and visualization methods.

Introduction

At the Kashiwa Campus of the National Cancer Center Japan (Hospital East and Exploratory Oncology Research and Clinical Trial Center), various clinical trials developing cancer treatment and diagnosis are being conducted, and high-quality clinical information is being accumulated. Using patient samples related to these clinical trials, multi-omics analyses such as single cell analysis, spatial transcriptome analysis, and microbiome analysis are being conducted within the center and in collaboration with laboratories at the Graduate School of Frontier Sciences, the University of Tokyo. These data are shared not only with researchers in academia, but also with pharmaceutical companies to identify new therapeutic targets and biomarkers. Furthermore, it is expected that various devices will be used to collect and utilize subjective symptoms and continuous vital data of the patients, which have been difficult to quantify. This information on the health status of individuals is essential for the development of future treatment and diagnosis methods, but at the same time, it must be strictly managed as personal information.
We would like to clarify what kind of technology is needed to build a safe, efficient, and consistent platform from data collection and management to efficient extraction of relevant information and visualization.

  • Extracting information from large-scale clinico-omics data

Biography

1993 M.D. Kanazawa University School of Medicine
2000 Ph.D. Graduate School of Medicine, Tokyo Dental and Medical University
1993-1994 Resident, Department of Surgery, Kanazawa University Hospital
1994-1995 Staff doctor, Takaoka Municipal Hospital
1998-2000 JSPS Research Fellow (DC2)
2000-2005 Postdoctoral Fellow, Ontario Cancer Institute/University Health Network, University of Toronto, Canada
2005-2013 Section Head, Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East
2011 Visiting Associate Professor, Laboratory of Cancer Biology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo
2013-2016 Chief, Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center Japan
2014-present Visiting Associate Professor, Laboratory of Cancer Biology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo
2016-2018 Chief, Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center Japan
2018-present Chief, Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center Japan