Inter-Institutional Cooperative Laboratories
Laboratory of Cancer Biology
YASUNAGA Masahiro Prof. M.D., Ph.D.
Other Affiliations: Chief, Division of Development Therapeutics
Drug delivery, Therapeutic antibody, Immunoregulation, Advanced mass
Antibody, DDS, Molecular imaging, Cell biology, Mass spectrometry, Smell and biomolecules.
Through my graduate school days, I was able to clarify the relationship between IL-7R signal and FYN as a cause of the abnormal cytokinesis in the immune cells. There, I learned the pleasure of the discovery for the first time. Subsequently, we conducted research on producing pancreatic β cells from ES cells for the type 1 diabetes treatment, which resulted in developing a method for monitoring and purifying endoderm stem cells via two specific antibodies. Currently, we are focusing on drug delivery systems (DDS). DDS technology would allow us to provide an ultimate anti-cancer drug with strong anti-tumor effects and without or fewer adverse effects. In addition, we are developing next-generation antibody drugs such as ADC (antibody-drug conjugate), RIT (radioimmunotherapy), and BsAb (bispecific antibody). We are also conducting unique drug discovery research utilizing molecular imaging and mass spectrometry analysis combined with informatics in order to visualize their delivery and the controlled drug release, and molecular cell biology methods to enhance the host immune reaction for the cure of cancer. Furthermore, we will develop a novel cancer diagnosis and treatment which target cancer smell and biomolecules. We welcome graduate students who are interested in our research.
|1988||Obtained M.D., Kumamoto University School of Medicine.|
|1996||Obtained Ph.D., Kumamoto University School of Medicine.|
|1989||Surgeon, Shimonoseki Kousei Hospital.|
|1993||Research Student, Graduate School of Medicine, Kyoto University.|
|1996||Surgeon, Tsuruta Hospital.|
|1997||Surgeon, Yamaga City Hospital.|
|1999||Surgeon, 1st Department of Surgery, Kumamoto University School of Medicine.|
|2002||Researcher, Stem cell biology, RIKEN CDB.|
|2006||Section head, Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East.|
|2012||Unit Leader, Developmental Therapeutics, Research Center for Innovative Oncology, National Cancer Center Hospital East.|
|2013||Visiting Associate Professor, NCC Cancer Science, Life Science and Technology Track, Tokyo Medical and Dental University.|
|2015||Unit leader, Division of Developmental Therapeutics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center.|
|Visiting Professor, Laboratory of Cancer Biology, Department of Integrated Biosciences, The University of Tokyo, Graduate School of Frontier Sciences.|
|2020||Chief, Division of Developmental Therapeutics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center.|
|2021||Visiting Professor, NCC Cancer Science, Life Science and Technology Track, Tokyo Medical and Dental University.|
|Visiting Professor, Medical Oncology and Translational Research, Graduate School of Medical Sciences, Kumamoto University.|