Inter-Institutional Cooperative Laboratories
Laboratory of Cancer Biology

Theme
Tumor biology, Drug Discovery, Pharmacology
Keyword
Chromosomal instability, DNA replication stress, Molecular target therapy, Multi-omics analysis
Introduction
In my Ph.D., I was dedicated to study cell cycle machineries of mouse preimplantation embryos in Reproductive Biology Laboratory, Graduate School of Agriculture, Kyoto University. This marked a decisive turning point in my carrier to live as a scientist for the rest of my life. In my postdoctoral training, switching research field from embryology to tumor biology, I worked for Dr. Junjie Chen and Dr. Fergus Couch at Mayo Clinic (Rochester, MN, USA) for four and half years to investigate molecular functions of BRCA2 gene, which is known as tumor suppressor genes in familial breast and ovarian cancers. After my postdoc, I worked for Oncology Drug Discovery Unit at Takeda Pharmaceutical Company Ltd. starting new carrier as an industry scientist. For 12 years as the industry scientist, I have experienced a series of drug discovery process from the beginning to the end: kick-off new projects, conduct preclinical studies form compound screening to clinical candidate selection, and build the translational/clinical strategies as global team members. In September 2018, I joined National Cancer Center, Kashiwa Campus, to lead basic and translational projects for development of novel cancer therapeutic drugs. I am committed to contribute to drug discovery of novel cancer therapeutics, especially Japan-oriented drug discovery in domestic and international collaborations with academia, pharmaceuticals, and biotech companies.
Biography
1993-1997 | Dep. Agriculture, Agriculture Engineering, Kyoto University (B.S.) |
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1997-1999 | Dep. Agriculture, Reproductive Biology, Kyoto University (M.S.) |
1999-2002 | Dep. Agriculture, Reproductive Biology, Kyoto University (Ph.D.) |
2002-2004 | Postdoctoral Fellow, Radiation Oncology, Mayo Clinic (Dr. Junjie Chen) |
2004-2006 | Postdoctoral Fellow, Laboratory Medicine and Pathology, Mayo Clinic (Dr. Fergus Couch) |
2006-2007 | Research Scientist, Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Ltd. |
2007-2016 | Senior Research Scientist, Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Ltd. |
2016-2017 | Group Head, Oncology Drug Discovery Unit, Takeda Pharmaceutical Company, Ltd. |
2017-2018 | Senior Scientist, Oncology Drug Discovery Unit, Takeda Pharmaceuticals International, Inc. |
2018-present | Division Head, Translational Genomics, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center |
2021-present | Adjunct Associate Professor, Division of Cancer Biology, Research Institute for Biomedical Sciences, Tokyo University of Science |
2022-present | Adjunct Associate Professor, Graduate School of Frontier Science, The University of Tokyo |