Inter-Institutional Cooperative Laboratories
Laboratory of Cancer Biology
ISHII Genichiro Prof. M.D., Ph.D.
Other Affiliations: Chief, Division of Innovative Pathology and Laboratory Medicine(Kashiwa)
Theme
Tumor biology, Cell biology, Pathology
Keyword
Tumor microenvironment, Cancer-associated fibroblasts. Diversity of drug sensitivity
Introduction
Cancer does not consist only of cancer cells. A large number of non-cancerous cells exist around cancer cells. During my graduate school days, I discovered that non-cancerous cells have functional abnormalities using human pathological specimens of malignant lymphoma. Since then, I have been consistently studying non-cancer cells, especially fibroblasts. Fibroblasts function either 1) as cells that fill tissue gaps or 2) as cells that directly influence the biological picture of cancer cells. Recent studies have recognized that fibroblasts are a functionally and phenotypically heterogeneous cell population. And cancer cells are also a heterogeneous cell population. We are developing in vitro models that mimic the dynamic microenvironment formed by these heterogeneous cancer cells and fibroblasts (tumor microenvironment dynamics) using techniques such as fluorescent proteins and time lapse imaging. In recent years, we have been using the above models to analyze the biological images of single cells (cancer cells and fibroblasts) in order to elucidate the mechanisms of cancer progression and drug sensitivity. If you are interested in this project, please contact us.
Biography
1990 | Obtained M.D., Kanazawa University School of Medicine. |
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1994 | Obtained Ph.D., Chiba University School of Medicine. |
1994 | Assistant Professor, Chiba University School of Medicine. |
2000 | Lecturer, Chiba University School of Medicine |
2001 | Section head, National Cancer Center Research Institute Kashiwa. |
2012 | Unit Leader, Developmental Therapeutics, Research Center for Innovative Oncology, |
National Cancer Center Hospital East. | |
2013 | Visiting Associate Professor, NCC Cancer Science, Life Science and Technology Track, Tokyo Medical and Dental University. |
2015 | Visiting Professor, Laboratory of Cancer Biology, Department of Integrated Biosciences, The University of Tokyo, Graduate School of Frontier Sciences. |
2016 | Chief, Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center. |
2020 | Chief, Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, East. |
Chief, Division of Innovative Pathology and Laboratory Medicine (Kashiwa) |